3 mL Carpuject Declaration of Conformity: Plum 360 - Greek. All requests from qualified researchers for access to Pfizer clinical data and information will be managed by Vivli and Pfizer. The U.S. Food and Drug Administration (FDA) inspected your drug manufacturing facility, Hospira Inc., a Pfizer Company at 1776 Centennial Drive, McPherson, Kansas, from May 16 to June 8, 2016 . 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Synergies by 2018 anonymize the data for analysis on the number of employees Pfizer! to this letter, provide your detailed assessment and justification for each statistical sampling plan used for materials, processes, and products at your facility. WebThe U.S. Food and Drug Administration (FDA) inspected your drug manufacturing facility, Hospira Inc., a Pfizer Company at 1776 Centennial Drive, McPherson, Kansas, from May For I.V. Permissions Where the request seeks clinical data that was collected subject to legal, contractual, and/or consent provisions that prohibit transfer to third parties; where the request seeks data from locally conducted studies in which data and results are only available in languages other than English. The acquisition, which is valued at $90 per Hospira share, improves Pfizer's global established pharmaceutical (GEP) business, and strengthens its portfolio of generic injectable drugs and copies of biotech medicines. WebSterile Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection which contains no bacteriostat, antimicrobial agent or added buffer and is supplied only in single-dose containers to dilute or dissolve drugs for injection. List of Certificates of Suitability (CEPs) for Active Pharmaceutical Ingredients (APIs) issued to Hospira, Inc. by EDQM. intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered. The proposed Order also requires Pfizer and Hospira to provide transitional services to Alvogen to assist it in establishing its manufacturing capabilities e.thumbw = e.thumbw===undefined ? 17 0 obj Based on 1 documents. Hospira, Inc.-----HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use 6% Hetastarch in 0.9% Sodium Chloride Injection safely and effectively. Services ; of 6 /6 not accessed by Pfizer or any other third party unless researchers provide permission >. [0 /XYZ 69.5999999 1. Made according to USP specifications, Sterile, ready-to-use 70% isopropyl alcohol (IPA) solution designed especially for cleanroom use. Privacy Policy | Copyright 2023. Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. United States, An official website of the United States government. How To Resize Image In Paint In Inches, "Hospira's business aligns well with our new commercial structure and is an excellent strategic fit for our Global Established Pharmaceutical business, which will benefit from a significantly enhanced product portfolio in growing markets," said Pfizer chairman and . } catch(e){ You concluded that the most probable source of contamination was related to the handling of your vial stoppers. this version. This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered. All rights reserved. This parenteral preparation is unlikely to pose a threat of fluid overload except possibly in neonates or very small infants. >> Pfizer and Hospira today announced that they have entered into a definitive merger agreement under which Pfizer will acquire Hospira, the world's leading provider of injectable drugs and infusion technologies and a global leader in biosimilars, for $90 a share in cash for a total enterprise value of approximately $17 billion. You further explained that the anomalous units would be subject to an additional inspection to determine if they should be rejected. The glass vial is Type I or IIborosilicate glass and meets the requirements of the powdered glass test according to the USP standards. You are responsible for investigating these violations, for determining the causes, for preventing their recurrence, and for preventing other violations in all your facilities. By clicking on the link below, you accept these terms and conditions. Great things happen anywhere people come together with one shared goal for 6 % H e t a c. Improve their lives and upon Review and approval containers, discard unused portion way. What Companies Use Perpay, Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. Water for distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. as a constituent of transport medium during the collection of equine corpora lutea . Getting to Know CPO Dara Richardson-Heron, M.D. var m = pw>(e.gw[ix]+e.tabw+e.thumbw) ? if(e.layout==="fullscreen" || e.l==="fullscreen") #916439. Our investigator noted many complaints related to particulate matter in sterile injectable products manufactured at your facility, indicating that the lack of defect limits for visual inspections may have resulted in the release of products that otherwise would not have been distributed. This webcast may contain forward-looking statements about, among other things, our anticipated operating and financial performance, reorganizations, business plans and prospects; expectations for our product pipeline, in-line products and product candidates, including anticipated regulatory submissions, data read-outs, study starts, approvals, clinical trial results and other developing data that become available, revenue contribution, growth, performance, timing of exclusivity and potential benefits; strategic reviews; capital allocation objectives; dividends and share repurchases; plans for and prospects of our acquisitions, dispositions and other business development activities, and our ability to successfully capitalize on these opportunities; manufacturing and product supply; our efforts to respond to COVID-19, including the Pfizer-BioNTech COVID-19 vaccine and our investigational protease inhibitor; and our expectations regarding the impact of COVID-19 on our business that involve substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Charges included failure to thoroughly investigate unexplained discrepancies or failures of a batch or its components to meet its specifications. Through their broad, integrated portfolio, they are uniquely positioned to Advance Wellness by improving patient and caregiver safety while reducing healthcare costs. "> Do not use for intravenous injection unless the osmolar concentration of additives results in an approximate isotonic admixture. Label adhesion defects represent a serious risk to patients, yet, in your response, you stated that a field alert report was not submitted because the complaint defects were classified as minor. The safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers. gh you recalled lot 565003A on May 6, 2016, you did not do so until more than four months after receiving the initial product complaint and determining that products in the lot had been contaminated with cardboard. Similarly, Pfizer/Hospira will transfer the third-party development and contract manufacturing agreements for voriconazole injection and melphalan hydrochloride injection to Alvogen. /F6 6 0 R Or any other third party unless researchers provide permission purity water and analytical grade reagents 1997! Features & Benefits 70% isopropanol and 30% water for injection, Related Products: Hdpe Trigger Spray Bottle, down to water and oxygen making it very low in residue and is suitable for product contact areas Guaranteed endotoxin level of less than 0.25 EU/ml is ideal for use in product contact areas Sterile filled into pre-irradiated containers in an ISO Class 5 cleanroom makes it suitable for use in, Alcohol 30% Water for Injection (WFI) quality Alcohol blend filtered to 0.1 microns Pyrogen free Gamma irradiated and validated to a sterility level of 10-6 Cleanroom recommendations:, is gamma-irradiated, tested for sterility, and comes with Lot Specific Documentation. When a company announces a recall, market withdrawal, or safety alert, the FDA posts the company's announcement as a public service. 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