Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. No additional iron to replenish stores. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Corrected Sodium and Effective Osmolality. Canada residents can call a provincial poison control center. Pain, swelling, or redness at the injection site may occur. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Fulminant symptoms may include general paleness, confusion or episodes of passing out. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). Do not administer Venofer to patients with iron overload. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Shirley, NY: American Regent, Inc.; 9/2020. Applies only to oral form of both agents. 1974 Jun;31(6):592-5. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). STORAGE: Consult the product instructions and your pharmacist for storage details. Use Caution/Monitor. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Use Caution/Monitor. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Avoid or Use Alternate Drug. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Administer on 5 different occasions over a 14 day period. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. Copyright(c) 2023 First Databank, Inc. Applies only to oral form of both agents. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Ferric gluconate: 12.5 mg/mL. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. The dosage of Venofer is expressed in mg of elemental iron. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Modify Therapy/Monitor Closely. Minor/Significance Unknown. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. iron sucrose, captopril. Applies only to oral form of both agents. 10th ed. Properly discard this product when it is expired or no longer needed. Avoid or Use Alternate Drug. Discard unused portion. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Most Applies only to oral form of both agents. 1970;100(7):301303. Minor/Significance Unknown. Controlled studies in pregnant women show no evidence of fetal risk. Iron sucrose: 20 mg/mL. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Ferrlecit may also be administered undiluted as a slow intravenous injection (at a rate of up to 12.5 mg/min) per dialysis session. [. Avoid or Use Alternate Drug. Use Caution/Monitor. Applies only to oral form of both agents. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] Total dose iron infusion: safety and efficacy in predialysis patients. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Applies only to oral form of both agents. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Applies only to oral form of both agents. Contraindicated. Share cases and questions with Physicians on Medscape consult. Dosing: (a) Divide calculated total cumulate dose . Use Caution/Monitor. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Venofer has not been studied in patients younger than 2 years old. Due Date form Ultrasound Report. Applies only to oral form of both agents. Adding plans allows you to compare formulary status to other drugs in the same class. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Use Caution/Monitor. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. For liquid medications, also enter the value of the Medicine Concentration and choose . Feraheme does not contain antimicrobial preservatives. iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. Either increases effects of the other by pharmacodynamic synergism. This information is not individual medical advice and does not substitute for the advice of your health care professional. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. iron sucrose increases levels of calcium chloride by enhancing GI absorption. 1970; 100(7):301-3. Avoid or Use Alternate Drug. Use Caution/Monitor. Applies only to oral form of both agents. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Iron sucrose: 20 mg/mL. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. commonly, these are "non-preferred" brand drugs. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). US residents can call their local poison control center at 1-800-222-1222. 1982;13(4):309-21. Contraindicated. Fatal reactions have also occurred in situations where the test dose was tolerated. Schweiz Med Wochenschr. UpToDate. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. Modify Therapy/Monitor Closely. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Applies only to oral form of both agents. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Monitor for signs and symptoms of hypotension following each administration of Venofer. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Recommended dosing and infusion rates for PI. Applies only to oral form of both agents. Drug class: Iron products. Applies only to oral form of both agents. Minor/Significance Unknown. 2.1 . The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. This may be helped by giving the medication more slowly or at a lower dose. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Use Caution/Monitor. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. Schweiz Med Wochenschr; 100(7):301-3. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. It is unlikely . Steps on how to print your input & results: 1. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer treatment may be repeated if iron deficiency reoccurs. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. These can be input in g/dL, g/L or mmol/L. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Venofer may reduce the absorption of concomitantly administered oral iron preparations. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. (3) Known hypersensitivity to Venofer. Applies only to oral form of both agents. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. 2000 Jan;22(1):39-43. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. 4. This health tool computes the iron deficit based on patient parameters and the Ganzoni formula. Sodium ferric gluconate (Ferrlecit) 62.5 mg . LBW = Lean body weight in kg. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Consult your pharmacist or local waste disposal company. We have found the lower dose to be better tolerated in the second half of gestation. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. 1995 Mar-Apr;11(2):163-8. Applies only to oral form of both agents. Use alternatives if available. elemental iron (mg/ml) in the product being used: Where C= Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. Applies only to oral form of both agents. ANNA J. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). The recipient will receive more details and instructions to access this offer. J Lab Clin Med; 111(5):566-70. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Pediatric Patients (2 Years of Age and Older). Most The dosage of Venofer is expressed in mg of elemental iron. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Nutr Clin Pract. Step 2: Calculation and administration of the maximum individual iron dose(s): . (See also Notes section. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. *Repeat dose if iron deficiency anemia reoccurs. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Applies only to oral form of both agents. Found in multiple references. Applies only to oral form of both agents. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Avoid or Use Alternate Drug. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Avoid or Use Alternate Drug. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Included in the iron dextran package insert. Applies only to oral form of both agents. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Observed Hb = the patients current hemoglobin in g/dl. Use Caution/Monitor. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? iron sucrose decreases levels of deferiprone by enhancing GI absorption. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. By using this form you agree with the storage and handling of your data by this website. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. *Administer early during the dialysis session. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Use alternatives if available. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. This document does not contain all possible drug interactions. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Interaction only with oral iron administration. 4. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Minor (1)iron sucrose, captopril. Do not administer Venofer to patients with evidence of iron overload. Applies only to oral form of both agents. May increase risk of hypotension. Applies only to oral form of both agents. Use Caution/Monitor. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. Reference www.medicines.org.uk Background 1 ,*. All Rights Reserved. 1) Ganzoni AM. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. The elemental iron product used is Iron sucrose 20 mg/mL. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Copyright 1993-2021 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Applies only to oral form of both agents. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Treatment of anemia due to iron deficiency. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Applies only to oral form of both agents. trientine, iron sucrose. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. All Rights Reserved. 1996 Aug;11(4):139-46. Applies only to oral form of both agents. DICP. an automated flowchart approach. 2010;18(3). Can't find what you need? Venofer must only be administered intravenously either by slow injection or by infusion. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. commonly, these are "preferred" (on formulary) brand drugs. Applies only to oral form of both agents. Applies only to oral form of both agents. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Venofer treatment may be repeated if necessary. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Separate by at least 4 hours. Use Caution/Monitor. This calculator will help pinpoint potential causes of anemia based on Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL vitamin E decreases levels of iron sucrose by increasing hepatic clearance. gymnema decreases levels of iron sucrose by inhibition of GI absorption. Avoid or Use Alternate Drug. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. The dosage of Venofer is expressed in mg of elemental iron. Administer while the patient is in a reclined or semi-reclined position. Individual plans may vary . Where: Medicine concentration Amount of active substance per a given volume of your drug. Do not mix iron sucrose with other medications or TPN solution. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Reactions have occurred following the first dose or subsequent doses of Venofer. Volume of iron product required = 25 mL. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Creating an account is free and takes less than 1 minute. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Kumpf VJ, Holland EG. Applies only to oral form of both agents. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Med J Aust; 193(9):525-32. Avoid or Use Alternate Drug. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Your doctor will do laboratory tests to monitor your response. 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